Enroute through Bone: Biology of Tooth Movement

Molecular Biology of Orthodontic Tooth Movement

The application of orthodontic forces to correct mandibular and maxillary teeth irregularities through alveolar bone remodeling involves a series of coordinated and regulated molecular and cellular events in the periodontium i.e. periodontal ligament (PL), alveolar bone (AB), cementum, and gingiva. The PL and AB are the two important structures which actively participate in bone remodeling in r...

Effect of Long-Term Captopril Administration on Bone Density and Orthodontic Tooth Movement

Background and Aim: Captopril is an oral angiotensin-converting-enzyme (ACE) inhibitor extensively used in the treatment of hypertension and heart failure. ACE has been suggested to function in bone cells and might therefore impact orthodontic tooth movement (OTM). Considering the controversy surrounding the effects of ACE and its inhibitors on osseous tissues, we aimed to evaluate the effect o...

Current concepts in the biology of orthodontic tooth movement.

Adaptive biochemical response to applied orthodontic force is a highly sophisticated process. Many layers of networked reactions occur in and around periodontal ligament and alveolar bone cells that change mechanical force into molecular events (signal transduction) and orthodontic tooth movement (OTM). Osteoblasts and osteoclasts are sensitive environment-to-genome-to-environment communicators...

Sclerostin Promotes Bone Remodeling in the Process of Tooth Movement

Tooth movement is a biological process of bone remodeling induced by mechanical force. Sclerostin secreted by osteocytes is mechanosensory and important in bone remodeling. However, little is known regarding the role of sclerostin in tooth movement. In this study, models of experimental tooth movement were established in rats and mice. Sclerostin expression was investigated with immunohistochem...

Bone bending, a feature of orthodontic tooth movement.